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When measuring cardiovascular effects, a low but statically significant increase in heart rate was noted but no significant effect on blood pressure at any of the doses tested

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, myeloperoxidase, leukotriene B4, tromboxane B2) (44), interacts with prostaglandin-dependent pathways (45, 46), has a direct protective and proliferative effect on target cells (18, 19), and modulates the release of nitric oxide (27)

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Insufficient blood supply delays the migration of immune cells and fibroblasts into tendons